Cytogenetic studies are available for peripheral blood, bone marrow and tissue investigations. Specimens must contain sufficient numbers of viable cells capable of mitosis. The type of anticoagulant, the freshness of the samples and the cellularity are all important variables.

Please provide sufficient clinical information to define the appropriate culture conditions. A variety of mitogens are available. For example, special mitogens for myeloid cells (GM-CSF) or for B-lymphocytes (phorbol ester) will be used if the working diagnosis of myelodysplasia or chronic lymphocytic leukemia accompanies the specimen. Each specimen will be cultured under at least two different culture systems to maximize metaphase recovery. Please see the Test Directory for specimen submission guidelines and Specimen Handling for specimen preparation and shipping guidelines.